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Keywords
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Pharmacologist,Pharmacist,Toxicologist,Measurement of Heavy Metals,Pharmacologic,Drug Transport,Diabetic Nephropathy,Membrane Transport,Distribution,Kidney Function
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Research and Practice Interests
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Research objectives: 1) Study of the mechanisms involved in the transport and metabolism of drugs and endogenous chemicals by the renal tubular epithelium, 2) elucidation of the mechanisms by which toxic substances damage the kidney.Principle methods Renal clearance, Sperber technique of renal portal infusion in birds, Renal slice and isolated proximal tubular cell incubations. Rat models of diabetes - Streptozotocin and galactosemia.Analytical techniques routinely employed include beta and gamma radioassay, atomic absorption and light spectroscopy Current interests center around study mechanisms involved in: 1) Nephrotoxicity of platinum-based anticancer agents; 2) Diabetes-induced alterations of proximal tubular cell function 3)Renal tubular active transport of anionic and cationic drugs.
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Community of Science Research Interests
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Research objectives: 1) Study of the mechanisms involved in the transport and metabolism of drugs and endogenous chemicals by the renal tubular epithelium, 2) elucidation of the mechanisms by which toxic substances damage the kidney.Principle methods Renal clearance, Sperber technique of renal portal infusion in birds, Renal slice and isolated proximal tubular cell incubations. Rat models of diabetes - Streptozotocin and galactosemia.Analytical techniques routinely employed include beta and gamma radioassay, atomic absorption and light spectroscopy Current interests center around study mechanisms involved in: 1) Nephrotoxicity of platinum-based anticancer agents; 2) Diabetes-induced alterations of proximal tubular cell function 3)Renal tubular active transport of anionic and cationic drugs.
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