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Professional Summary
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Dr. Pauletti is an Associate Professor of Biopharmaceutics & Pharmacokinetics at the James L. Winkle College of Pharmacy. His research interests focus on molecular pharmaceutics with an emphasis on membrane transport. Current activities include rational design, fabrication, and evaluation of innovative, non-viral nanocarriers as vectors for targeted drug delivery applications to improve therapeutic efficacy of small molecules, biotechnology drugs, and antitumor agents. Dr. Pauletti has published more than 80 scientific abstracts and papers. He is an inventor on 15 U.S. patents and patent applications protecting various drug delivery technologies and contributed to one GenBank entry. Dr. Pauletti served on more than 35 MS/PhD committees and is engaged in the education of professional PharmD and MS/PhD students enrolled in Pharmaceutical Sciences and Engineering graduate programs. As an advisor to pharmaceutical companies, Dr. Pauletti has facilitated preclinical and early clinical development of different molecular entities relevant to women’s health and cancer therapy.
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Research Support
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2008
2008
UC Institute for Nanoscale Science & Technology:
"Development of Peptide-functionalized Nanotubes for Needle-free Oral Vaccination"
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2005
2008
National Institute of Child Health & Human Development:
"Peptide Ligands for Transplacental Transcytosis Receptors"
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2003
2007
National Institute of Medical Sciences:
"Vaginal Delivery of P-Glycoprotein Substrates"
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Publications
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Published Abstracts
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Shaik, S.B., Ellinger, I., and Pauletti, G.M. (2008). Prediction of Peptide Sequences with Balanced Affinity and Dissociation Profiles for the Human Neonatal Fc-Receptor [Abstract]. AAPS National Biotechnology Conference, June 22-25, Toronto, Ontario (Canada) This presentation was selected for an "Innovative Research Award".
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Shaik, S.B., Trisal, P., Balasubramaniam, A., Menon, A.G., and Pauletti, G.M. (2007). Integrin-binding peptide facilitate transcytosis of T7 bacteriophages across the human placenta in vitro [Abstract]. AAPS National Biotechnology Conference, June 24-27, San Diego, CA.
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Shaik, S.B., Jegga, A., Menon, A.G., and Pauletti, G.M. (2007). Identification of Novel Peptide Ligands for Putative Transcytosis Receptors Expressed in the Human Placenta [Abstract]. Annual Meeting of the AAPS, November 11-15, San Diego, CA.
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Li, F., Kulkarni, A., Pauletti, G.M., and Desai, P. (2007). Influence of BAS 100, a Spiro-ortho Ester, Isolated from Grapefruit Juice on the Activity and Expression of Drug Metabolizing Enzymes and Transporters [Abstract]. Annual Meeting of the AAPS, November 11-15, San Diego, CA.
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Peer Reviewed Publications
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Guo, Y., Shi, D., Cho, H., Dong, Z., Kulkarni, A., Pauletti, G.M., Wang, W., Lian, J., Liu, W., Ren, L., Liu, G., Huth, C., Wang, L., and Ewing, R.C. (2008). In vivo Imaging and Drug Storage by Quantum Dot-conjugated Carbon Nanotubes. Adv. Funct. Mat., (in press).
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Kawedia, J., Jian, M., Kulkarni, A., Waechter, H.E., Matlin, K.S., Pauletti, G.M., and Menon, A.G. (2008). The PKA Pathway Contributes to Hg++–induced Alterations inPhosphorylation and Subcellular Distribution of Occluding Associated with Increased Tight Junction Permeability of Salivary Epithelial Cell Monolayers. J. Exp. Pharmacol. Ther., (in press).
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Moayed, F.A., Pauletti, G.M., Shell, R.L., and Genaidy, A. (2008). Experimental Design Comparison of Studies Evaluating Doxorubicin Nanoparticles in Breast Cancer Therapy. Hum. Factors Ergonom. Manufact., 18, 342-357.
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Narang, V.S., Pauletti, G.M., Gout, P.W., Buckley, D.J., and Buckley, A.R. (2006). Sulfasalazine-induced reduction in glutathione levels in breast cancer cells: enhancement of growth-inhibitory activity of doxorubicin. Chemotherapy, 53, 210-217.
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Dixit, S.G., Zingarelli, B., Buckley, D.J., Buckley, A.R., and Pauletti, G.M. (2005). Nitric oxide mediates increased P-glycoprotein activity in interferon-g-stimulated human intestinal cells. Am. J. Physiol., 288, G533-G540.
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Honors and Awards
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2008
Editorial Board Member, European Journal of Pharmaceutics & Biopharmaceutics
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2008
Chair Scientific Planning Committee, AAPS National Biotechnology Conference
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2007
Commencement Keynote Speaker, University of Toledo, College of Pharmacy
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2006
Faculty Research Recognition Award, University of Cincinnati, College of Pharmacy
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2000
Editorial Board Member, Journal of Herbal Pharmacotherapy
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1999
Member, Rho Chi Honor Society
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1994
Postdoctoral Research Fellowship, Swiss National Science Foundation
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Education
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Institution:Swiss Federal Institute of Technology
Zurich (ETHZ), Switzerland
BS - Pharmacy (1987)
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Institution:Swiss Federal Institute of Technology
Zurich (ETHZ), Switzerland
PhD - Biopharmaceutics/Pharmacokinetics (1994)
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Post Graduate Training & Education
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Postdoctoral Fellow - Peptide Drug Delivery (1993 - 1997)
The University of Kansas, Pharmaceutical Chemistry Department (Dr. Ronald T. Borchardt)
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Keywords
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Nanopharmaceutics, targeted drug delivery, membrane transport
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Research and Practice Interests
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Research interests focus on molecular pharmaceutics with an emphasis on membrane transport. Current activities include rational design, fabrication, and evaluation of innovative, non-viral nanocarriers as vectors for targeted drug delivery applications to improve therapeutic efficacy of small molecules, biotechnology drugs, and antitumor agents. Specifically, we apply phage display technology to identify unique peptide ligands that facilitate selective intracellular delivery and/or transepithelial transport of colloidal nanocarriers such as nanoparticles, liposomes, and niosomes. In addition, we are engaged in collaborative research projects with UC faculty in Material Science and Internal Medicine aimed at developing multifunctional nanocomposite structures suitable for drug delivery and non-invasive imaging applications.
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Other Information
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Description:Current research team members include:
Amit Kulkarni (PhD student)
Shruthi Vaidhyanathan (PhD student)
Bunyong Sombunsakdikun (MS student)
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