Publications
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Peer Reviewed Publications
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Plageman, L., Pauletti, G. M. and, Skau, K.A. (2002). Characterization of Acetylcholinesterase in Caco-2 Cells. Exp. Biol. Med, 227, 480-486.
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Age-related Changes in Activity of AChE Molecular Forms in Fisher 344 Rats. (1998). Age-related Changes in Activity of AChE Molecular Forms in Fisher 344 Rats. Molec. Chem. Neuropath, 35, 13-21.
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Hammer, D.P., Sauer, K.A., Fielding, D.W., Skau, K.A. (2004). White Paper on Best Evidence Pharmacy Education (BEPE). American Journal of Pharmacy Education, 68:, 24.
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Syed, M., Fenoglio-Preiser, C., Skau, K. A. Weber, G. F.: (2008). Acetylcholinesterase Supports Anchorage Independence in Colon Cancer. Clin. Exp. Metastasis, 25, 787-798.Co-Author
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Brown, B., Skau, K., Wall, A (2009). Learning Across the Curriculum: Connecting the Basic Sciences to Practice in the First Professional Year. Am. J. Pharm. Ed., 73(2), Article 36.Co-Author
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Other Publications
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Skau, K.
(2007).
Pharmacy is a Science-based Profession.
American Journal of Pharmacy Education
,71:
11
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Skau, K.
(2004).
Teaching Pharmacodynamics: An Introductory Module On Learning Dose-Response Relationships..
American Journal of Pharmacy Education
,68:
73
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Honors and Awards
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2003
Faculty Excellence Award University of Cincinnati Rho Chi Honor Society
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1997
Faculty Excellence Award University of Cincinnati Rho Chi Honor Society
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1995
Faculty Excellence Award University of Cincinnati Rho Chi Honor Society
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1991
Faculty Excellence Award University of Cincinnati Rho Chi Honor Society
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1987
Faculty Excellence Award University of Cincinnati Rho Chi Honor Society
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1978
National Research Service Award NIH
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2007
The Jack L. Beal Postbaccalaureate Award from The Ohio State University College of Pharmacy
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2007
Fellow, Academy of Fellows for Teaching and Learning.
Inaugural class of Fellows in this Academy.
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2008
First Professional Year Faculty Excellence Award
Recognition
Recipient
College
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2008
Innovations in Teaching Award.
A co-recipient of the 2008 AACP Innovations in Teaching Award. Beth Brown is the Principal Awardee.
Recognition
American Association of Colleges of Pharmacy.
Recipient
National
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1989
-1989
Outstanding Professional Educator
Recognition
American Diabetes Association, Ohio Affiliate, Cincinnati Chapter
Recipient
Professional Org.
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Education
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Institution:Ohio State University
Columbus, OH
Ph.D.
/77/1977
Pharmacology
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Institution:Ohio State University
Columbus, OH
B.S.
/70/1970
Pharmacy
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Keywords
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Cholinesterases,Pharmacology,Enzyme Inhibitors,Cholinergics,Acetylcholinesterase,Butyrylcholinesterase, Lipid rafts
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Research and Practice Interests
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My research centers around biochemical and pharmacological aspects of the cholinesterases. A major focus has been on the distribution of molecular forms of these enzymes primarily in excitable tissues. In addition, we are studying alternative functional roles of these enzymes. There are indications that they may be involved in cell adhesion and perhaps other non-hydrolytic functions. We are also examining the xenobiotic role of cholinesterases in metabolism of certain drugs.
Recent work in my lab has focused on cholinesterases in Caco-2 cells. We have strong evidence that acetylcholinesterase in Caco-2 cells is a GPI-anchored protein located in lipid rafts on the apical side of these polarized, epithelial derived cells.
My research and expertise includes the following: The biology and pharmacology of the cholinesterases. I investigate the distribution and function of the cholinesterases in various tissues including neuronal, muscular, cardiac and smooth muscle. I also use the distribution of these enzymes as tools for the study of changes in these tissues in various pathological states. For example, I have done extensive studies on changes associated withmuscular dystrophy, diabetic neuropathies and diabetic cardiomyopathies. Various drugs that inhibit the cholinesterases are useful in certain diseases, such as Alzheimer's disease. I have investigated the mechanisms by which these drugs act.
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Community of Science Research Interests
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My research centers around biochemical and pharmacological aspects of the cholinesterases. A major focus has been on the distribution of molecular forms of these enzymes primarily in excitable tissues. In addition, we are studying alternative functional roles of these enzymes. There are indications that they may be involved in cell adhesion and perhaps other non-hydrolytic functions. We are also examining the xenobiotic role of cholinesterases in metabolism of certain drugs.
Recent work in my lab has focused on cholinesterases in Caco-2 cells. We have strong evidence that acetylcholinesterase in Caco-2 cells is a GPI-anchored protein located in lipid rafts on the apical side of these polarized, epithelial derived cells.
My research and expertise includes the following: The biology and pharmacology of the cholinesterases. I investigate the distribution and function of the cholinesterases in various tissues including neuronal, muscular, cardiac and smooth muscle. I also use the distribution of these enzymes as tools for the study of changes in these tissues in various pathological states. For example, I have done extensive studies on changes associated withmuscular dystrophy, diabetic neuropathies and diabetic cardiomyopathies. Various drugs that inhibit the cholinesterases are useful in certain diseases, such as Alzheimer's disease. I have investigated the mechanisms by which these drugs act.
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Other Experience and Professional Memberships
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2007
Academy of Fellows of Teaching and Learning
Elected Secretary/Treasurer for 2009-2011.
University of Cincinnati
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1999
American Society for Pharmacology and Experimental Therapeutics
Part of the Federation of American Societies of Experimental Biology
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1982
American Association of Colleges of Pharmacy,
Served as Secretary of Section of Teachers of Biological Sciences (1994-98), Chair of the Section of Teachers of Biological Sciences (1999-2000), Chair-elect, Chair and Past Chair of the Council of Faculties (2005-08), Board of Directors (2005-08).
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1970
American Pharmacists Association
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1976
American Association for the Advancement of Science
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1979
-2005
Society for Neurosciences
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1980
-2003
New York Academy of Sciences
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1974
Rho Chi
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1976
-1985
Sigma Xi
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1985
-1992
American Diabetes Association.
Board of Directors, Cincinnati Chapter 1985-90; Board of Directors, Ohio Affiliate 1989-92
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Courses Taught
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25-PBIO-624 PRIN PHARMACOLOGY
Instr. Method:Lecture and Active Learning Methods
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25-PBIO-502 VITAMINS
Instr. Method:Lecture and Student Presentations
Max Enroll:25
An elective course to help students learn when it is appropriate or inappropriate to use
FDA recognized vitamins for nutrition or for therapeutics of disease conditions.
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25-PHTH-733 THER ENDOCRINE DISO
I teach the pharmacology associated with drugs used to treat endocrine disorders.
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Other Information
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Description:Editorial Board, Currents in Pharmacy Teaching and Learning 2009-
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